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Real exchange rate is one of those factors whose misalignment from equilibrium and volatility will affect the performance of macroeconomics and economic growth in particular. The present article is an empirical study of the undesireable effect of these two phenomenas of exchange rate system on macroeconomic growth of iran during 1959 up to 2004. To do this, I use GARCH model to estimate the volatility index of real exchange rate, and also I use three criterias, to measure the amount of real exchange rate misalignment. An estimation of the model of Iranian economic growth through different indices indicates that volatility and the real exchange rate misalignment, have a negative effect on Iranian economic growth.